Streptomycin

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Streptomycin is an antibiotic medication used to treat a number of bacterial infections. This includes tuberculosis, Mycobacterium avium complex, endocarditis, brucellosis, Burkholderia infection, plague, tularemia, and rat bite fever.

What drug class is Streptomycin

Streptomycin belongs to a class of drugs known as aminoglycoside antibiotics. It works by killing the organisms that cause the infection. This drug may also be used to treat other serious infections along with other medications.

When should I take Streptomycin

This medication is used with other medications to treat active tuberculosis (TB) infection if you cannot take other drugs for TB or if you have a type of TB that cannot be treated with other drugs (drug-resistant TB). Streptomycin belongs to a class of drugs known as aminoglycoside antibiotics.

What are the side effects of Streptomycin

  • nausea
  • vomiting
  • stomach upset
  • loss of appetite
  • spinning sensation (vertigo)
  • injection site reactions (pain, irritation, and redness)
  • tingling or prickling sensation in the face
  • rash

What is the indication of Streptomycin 

Moderate to severe susceptible infections, including plague, tularemia, endocarditis. Second-line therapy for gram-negative bacillary bacteremia, meningitis, pneumonia, brucellosis, granuloma inguinale, chancroid, UTIs .


What is the contraindication of Streptomycin 

diarrhea from an infection with Clostridium difficile bacteria. low amount of calcium in the blood. dehydration. a type of movement disorder called parkinsonism.

Why is streptomycin so effective

Streptomycin kills bacteria by compromising the ribosome. Streptomycin is an effective antibiotic because its structure is similar to that of the anticodons that would usually bind to the ribosome. Streptomycin is significant because it was the first antibiotic that could treat tuberculosis.

What is the target of streptomycin

Streptomycin irreversibly binds to the 16S rRNA and S12 protein within the bacterial 30S ribosomal subunit. As a result, this agent interferes with the assembly of initiation complex between mRNA and the bacterial ribosome, thereby inhibiting the initiation of protein synthesis.



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